MED25

Chr 19q13.33

mediator complex subunit 25

Aliases:: ARC92, ACID1, TCBAP0758, DKFZp434K0512
MANE:: ENST00000312865.10

OMIM: 610197 ↗NCBI: 81857 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

MED25 · Q71SY5

v62025-08-01

Predicted Aligned Error matrix for MED25 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

62.5/ 100

Low

747 residues

Confidence breakdown

Very high(≥ 90)25%
Confident(70–90)19%
Low(50–70)8%
Very low(< 50)48%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Clefting
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Corneal abnormalities
BIALLELIC, autosomal or pseudoautosomal
Hereditary neuropathy
BIALLELIC, autosomal or pseudoautosomal
Hereditary neuropathy or pain disorder
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

congenital cataract-microcephaly-nevus flammeus simplex-severe intellectual disability syndrome
0.77
neurodegenerative disease
0.54
Charcot-Marie-Tooth disease type 2B2
0.51
hereditary disease
0.47
Tip-toe gait
0.46
Charcot-Marie-Tooth disease type 2
0.42
syndromic intellectual disability
0.37
autosomal recessive non-syndromic intellectual disability
0.37
Neurodevelopmental delay
0.33
neurodevelopmental disorder
0.30

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Mediator of RNA polymerase II transcription subunit 9

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors