AlphaFold predicted structure
MGAT2 · Q10469
Mean pLDDT
84.9/ 100
Confident
447 residues
Confidence breakdown
- Very high(≥ 90)72%
- Confident(70–90)6%
- Low(50–70)4%
- Very low(< 50)18%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
MGAT2
Chr 14q21.3alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- Aliases:
- GNT-II
- MANE:
- ENST00000305386.4
Annotations refreshed 10 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Congenital disorders of glycosylation
BIALLELIC, autosomal or pseudoautosomalDDG2P
BIALLELIC, autosomal or pseudoautosomalIntellectual disability
BIALLELIC, autosomal or pseudoautosomalLikely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomalUndiagnosed metabolic disorders
BIALLELIC, autosomal or pseudoautosomalFetal anomalies
BIALLELIC, autosomal or pseudoautosomalChildhood onset dystonia, chorea or related movement disorder
Fetal hydrops
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
MGAT2-congenital disorder of glycosylation
0.78congenital disorder of glycosylation
0.37congenital disorder of glycosylation type II
0.37COVID-19
0.37Abnormal glycosylation
0.26Abnormal facial shape
0.26Global developmental delay
0.26hereditary disease
0.19autoimmune disorder of musculoskeletal system
0.06corneal neovascularization
0.06
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Plays an essential role in protein N-glycosylation. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans