AlphaFold predicted structure
MICA · Q29983
Mean pLDDT
81.7/ 100
Confident
383 residues
Confidence breakdown
- Very high(≥ 90)59%
- Confident(70–90)19%
- Low(50–70)6%
- Very low(< 50)18%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
MICA
Chr 6p21.33MHC class I polypeptide-related sequence A
- Aliases:
- PERB11.1
- MANE:
- ENST00000449934.7
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
COVID-19 research
UnknownFamilial Meniere Disease
Primary immunodeficiency or monogenic inflammatory bowel disease
Unknown
Disease associations (Open Targets)
psoriasis
0.38psoriatic arthritis
0.37inborn error of immunity
0.18neoplasm
0.12hepatocellular carcinoma
0.12hypothyroidism
0.12Miyoshi myopathy
0.11pancreatic neoplasm
0.11familial pancreatic carcinoma
0.11breast cancer
0.11
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
MHC class I polypeptide-related sequence A
Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8 alphabeta T-cells (PubMed:11491531, PubMed:11777960). Up-regulated in stressed conditions, such as viral and bacterial infections or DNA damage response, serves as signal of cellular stress, and engagement of KLRK1/NKG2D by MICA triggers NK-cells resulting in a range of immune effector functions, such as cytotoxicity and cytokine production (PubMed:10426993)
Diseases associated with MICA
Curated MONDO disease pages that list MICA among their top associated genes.