MIF

Chr 22q11.23

macrophage migration inhibitory factor

Aliases:: GIF
MANE:: ENST00000215754.8

OMIM: 153620 ↗NCBI: 4282 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

MIF · P14174

v62025-08-01

Predicted Aligned Error matrix for MIF — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

98.6/ 100

Very high

115 residues

Confidence breakdown

Very high(≥ 90)100%
Confident(70–90)0%
Low(50–70)0%
Very low(< 50)0%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

COVID-19 research
Unknown
Familial Meniere Disease

Disease associations (Open Targets)

rheumatoid arthritis
0.68
juvenile idiopathic arthritis
0.43
systemic-onset juvenile idiopathic arthritis
0.42
cystic fibrosis
0.39
chronic graft versus host disease
0.26
osteoarthritis, hand
0.18
neoplasm
0.12
Alzheimer disease
0.12
breast cancer
0.12
hepatocellular carcinoma
0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Anti-Muellerian hormone

The anti-Muellerian hormone (AMH) plays an important role in several reproductive functions (PubMed:14742691, PubMed:34155118, PubMed:3754790, PubMed:8469238). Anti-Muellerian hormone binds and activates AMHR2, its specific type-II receptor, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A) to regulate target gene expression through downstream SMAD protein signal transduction (PubMed:20861221, PubMed:34155118). Produced and secreted by Sertoli cells of the male fetus, anti-Muellerian hormone induces Muellerian duct regression during male fetal sexual differentiation (PubMed:34155118, PubMed:3754790, PubMed:8469238). In female, it is produced by granulosa cells of the preantral and small antral follicles and acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles (PubMed:14742691). Also plays a role in Leydig cell differentiation and function (By similarity)

Curated MONDO disease pages that list MIF among their top associated genes.

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Disease associations (Open Targets)

Protein function (UniProt)

Diseases associated with MIF