MIP

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Bilateral congenital or childhood onset cataracts

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Structural eye disease

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

• Total congenital cataract

  0.79

• Cataract with Y-shaped suture opacities

  0.79

• cataract

  0.71

• early-onset non-syndromic cataract

  0.69

• lens disorder

  0.58

• Abnormal lens morphology

  0.58

• Developmental cataract

  0.56

• eye adnexa disorder

  0.55

• hereditary disease

  0.42

• Posterior polar cataract

  0.40

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Diseases associated with MIP

Curated MONDO disease pages that list MIP among their top associated genes.

• early-onset non-syndromic cataractRare
• cataractRare
• early-onset zonular cataractRare