MLIP

Chr 6p12.1

muscular LMNA interacting protein

Aliases:: MGC18257, CIP
MANE:: ENST00000502396.6

OMIM: 614106 ↗NCBI: 90523 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

MLIP · Q5VWP3

v62025-08-01

Predicted Aligned Error matrix for MLIP — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

43.3/ 100

Very low

993 residues

Confidence breakdown

Very high(≥ 90)2%
Confident(70–90)4%
Low(50–70)15%
Very low(< 50)80%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Acute rhabdomyolysis
BIALLELIC, autosomal or pseudoautosomal
Congenital myopathy
BIALLELIC, autosomal or pseudoautosomal
Rhabdomyolysis and metabolic muscle disorders
BIALLELIC, autosomal or pseudoautosomal
Cardiac arrhythmias - additional genes
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

myopathy with myalgia, increased serum creatine kinase, and with or without episodic rhabdomyolysis 1
0.74
Abnormality of the skeletal system
0.42
Abnormal urine sodium concentration
0.41
heart failure
0.38
systolic heart failure
0.36
intellectual developmental disorder, autosomal dominant 64
0.34
hypertrophic cardiomyopathy
0.32
placental abruption
0.29
response to selective serotonin reuptake inhibitor
0.27
response to statin
0.27

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Muscular LMNA-interacting protein

Required for myoblast differentiation into myotubes, possibly acting as a transcriptional regulator of the myogenic program (By similarity). Required for cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays a role in the protection against cardiac hypertrophy (By similarity). Binds chromatin (By similarity). May act as a transcriptional cofactor for ISL1, repressing its transcriptional activity (By similarity). May also repress MYOCD transcriptional activity (By similarity)