MMP9

Chr 20q13.12

matrix metallopeptidase 9

MANE:: ENST00000372330.3

OMIM: 120361 ↗NCBI: 4318 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

MMP9 · P14780

v62025-08-01

Predicted Aligned Error matrix for MMP9 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

82.1/ 100

Confident

707 residues

Confidence breakdown

Very high(≥ 90)49%
Confident(70–90)33%
Low(50–70)5%
Very low(< 50)13%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Skeletal dysplasia
BIALLELIC, autosomal or pseudoautosomal
Familial Meniere Disease
Osteogenesis imperfecta

Disease associations (Open Targets)

metaphyseal anadysplasia
0.66
dengue disease
0.48
Crohn disease
0.41
intervertebral disk degenerative disorder
0.38
non-small cell lung carcinoma
0.38
gastric adenocarcinoma
0.37
ulcerative colitis
0.32
breast cancer
0.31
prostate cancer
0.31
COVID-19
0.30

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Matrix metalloproteinase-9

Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration (PubMed:12879005, PubMed:1480034, PubMed:2551898). Could play a role in bone osteoclastic resorption (By similarity). Cleaves KiSS1 at a Gly-|-Leu bond (PubMed:12879005). Cleaves NINJ1 to generate the Secreted ninjurin-1 form (PubMed:32883094). Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (PubMed:1480034). Degrades fibronectin but not laminin or Pz-peptide