MOG

Chr 6p22.1

myelin oligodendrocyte glycoprotein

Aliases:: BTN6, BTNL11
MANE:: ENST00000376917.8

OMIM: 159465 ↗NCBI: 4340 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

MOG · Q16653

v62025-08-01

Predicted Aligned Error matrix for MOG — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

84.8/ 100

Confident

247 residues

Confidence breakdown

Very high(≥ 90)48%
Confident(70–90)36%
Low(50–70)15%
Very low(< 50)0%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Kleine-Levin syndrome
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Paroxysmal central nervous system disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

transient neonatal diabetes mellitus
0.54
narcolepsy-cataplexy syndrome
0.51
hereditary disease
0.19
monogenic diabetes
0.17
myeloid sarcoma
0.12
Alzheimer disease
0.12
acute disseminated encephalomyelitis
0.11
myelitis
0.11
neuromyelitis optica
0.11
optic neuritis
0.10

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Myelin-oligodendrocyte glycoprotein

Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication