MPZL2

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Monogenic hearing loss

  BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

• hearing loss, autosomal recessive

  0.71

• Non-syndromic genetic deafness

  0.38

• nonsyndromic genetic hearing loss

  0.37

• deafness

  0.36

• hereditary disease

  0.34

• Splenomegaly

  0.33

• lung adenocarcinoma

  0.27

• non-autoimmune hemolytic anemia

  0.26

• lung cancer

  0.23

• non-small cell lung carcinoma

  0.16

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)