MRAP

Chr 21q22.11

melanocortin 2 receptor accessory protein

Aliases:: B27, FALP, MRAP1
MANE:: ENST00000303645.10

OMIM: 609196 ↗NCBI: 56246 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

MRAP · Q8TCY5

v62025-08-01

Predicted Aligned Error matrix for MRAP — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

58.1/ 100

Low

172 residues

Confidence breakdown

Very high(≥ 90)11%
Confident(70–90)6%
Low(50–70)47%
Very low(< 50)36%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Congenital adrenal hypoplasia
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability

Disease associations (Open Targets)

familial glucocorticoid deficiency
0.71
hypertensive disorder
0.50
atrial fibrillation
0.43
Increased blood pressure
0.39
Cytomegalic congenital adrenal hypoplasia
0.37
response to xenobiotic stimulus
0.32
Abnormality of the skeletal system
0.32
cardiovascular disorder
0.32
essential hypertension
0.32
hereditary disease
0.19

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Melanocortin-2 receptor accessory protein

Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells