MRAS

Chr 3q22.3

muscle RAS oncogene homolog

Aliases:: M-RAs, R-RAS3, RRAS3
MANE:: ENST00000423968.7

OMIM: 608435 ↗NCBI: 22808 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

MRAS · O14807

v62025-08-01

Predicted Aligned Error matrix for MRAS — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

86.4/ 100

Confident

208 residues

Confidence breakdown

Very high(≥ 90)72%
Confident(70–90)10%
Low(50–70)5%
Very low(< 50)13%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Paediatric or syndromic cardiomyopathy
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
RASopathies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Monogenic short stature
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

Noonan syndrome 11
0.70
Noonan syndrome
0.66
coronary artery disorder
0.49
hypertensive disorder
0.47
type 2 diabetes mellitus
0.43
myocardial infarction
0.42
RASopathy
0.41
coronary atherosclerosis
0.41
Increased blood pressure
0.37
carcinoma of esophagus
0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Ras-related protein M-Ras

Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (PubMed:16630891, PubMed:28289718, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:16630891, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The formation of the SMP complex only occurs when MRAS is GTP-bound (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39809765). Unlike other Ras proteins, MRAS has low intrinsic GTPase activity and may require additional factors for activation (PubMed:39809765). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:16630891, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). Recognized by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (PubMed:40934300)