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GenoLensGenoLens

MRC1

Chr 10p12.33

mannose receptor C-type 1

Aliases:
CLEC13D, CD206, bA541I19.1, CLEC13DL
MANE:
ENST00000569591.3
OMIM: 153618 ↗NCBI: 4360 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

  • COVID-19 research

    Unknown

Disease associations (Open Targets)

  • tuberculosis

    0.38

  • dengue disease

    0.37

  • hypothyroidism

    0.35

  • metabolic dysfunction-associated steatotic liver disease

    0.33

  • Alzheimer disease

    0.27

  • thyroid gland disorder

    0.25

  • Varicose veins

    0.23

  • neoplasm

    0.12

  • breast carcinoma

    0.11

  • breast cancer

    0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Macrophage mannose receptor 1

Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains

Diseases associated with MRC1

Curated MONDO disease pages that list MRC1 among their top associated genes.

Data sources: HGNC (CC BY 4.0), AlphaFold (CC BY 4.0, Jumper et al. Nature 2021), Genomics England PanelApp (CC BY 4.0), ClinGen, Open Targets (CC0), UniProt.

Not for sole clinical decision-making. Always verify against primary sources.