AlphaFold predicted structure
MRPS2 · Q9Y399
Mean pLDDT
82.3/ 100
Confident
296 residues
Confidence breakdown
- Very high(≥ 90)71%
- Confident(70–90)3%
- Low(50–70)5%
- Very low(< 50)21%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
MRPS2
Chr 9q34.3mitochondrial ribosomal protein S2
- Aliases:
- CGI-91, uS2m
- MANE:
- ENST00000241600.10
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
DDG2P
BIALLELIC, autosomal or pseudoautosomalLikely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomalMitochondrial disorders
BIALLELIC, autosomal or pseudoautosomalPossible mitochondrial disorder - nuclear genes
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
combined oxidative phosphorylation deficiency 36
0.73mitochondrial disease
0.19inborn mitochondrial metabolism disorder
0.19Isolated anophthalmia - microphthalmia
0.08nanophthalmia
0.07microphthalmia, isolated, with coloboma
0.06microphthalmia
0.06isolated microphthalmia 7
0.06Microphthalmia - cataract
0.05liver disorder
0.05
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Small ribosomal subunit protein uS2m
Required for mitoribosome formation and stability, and mitochondrial translation