AlphaFold predicted structure
MSRB3 · Q8IXL7
Mean pLDDT
85.3/ 100
Confident
192 residues
Confidence breakdown
- Very high(≥ 90)70%
- Confident(70–90)2%
- Low(50–70)19%
- Very low(< 50)9%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
MSRB3
Chr 12q14.3methionine sulfoxide reductase B3
- Aliases:
- FLJ36866, DKFZp686C1178
- MANE:
- ENST00000308259.10
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Monogenic hearing loss
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
hearing loss, autosomal recessive
0.65deafness
0.50atrial fibrillation
0.40sleep apnea syndrome
0.40Snoring
0.40Non-syndromic genetic deafness
0.38hearing loss disorder
0.37nonsyndromic genetic hearing loss
0.37obstructive sleep apnea syndrome
0.36odontogenesis
0.36
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Methionine-R-sulfoxide reductase B3
Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing