MT-CYB

Chr mitochondria

mitochondrially encoded cytochrome b

Aliases:: COB, CYTB, UQCR3

OMIM: 516020 ↗NCBI: 4519 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

MT-CYB · P00156

v62025-08-01

Predicted Aligned Error matrix for MT-CYB — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

97.8/ 100

Very high

380 residues

Confidence breakdown

Very high(≥ 90)99%
Confident(70–90)1%
Low(50–70)0%
Very low(< 50)0%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Likely inborn error of metabolism
MITOCHONDRIAL
Mitochondrial disorders
MITOCHONDRIAL
Undiagnosed metabolic disorders
MITOCHONDRIAL
Albinism or congenital nystagmus
MITOCHONDRIAL
Infantile nystagmus
MITOCHONDRIAL
Childhood onset dystonia, chorea or related movement disorder
MITOCHONDRIAL
Sudden death in young people
MITOCHONDRIAL

Disease associations (Open Targets)

Leber hereditary optic neuropathy
0.69
histiocytoid cardiomyopathy
0.63
mitochondrial disease
0.63
Exercise intolerance
0.62
mitochondrial encephalomyopathy
0.62
MELAS syndrome
0.55
mitochondrial myopathy with reversible cytochrome C oxidase deficiency
0.51
maternally-inherited diabetes and deafness
0.45
inborn mitochondrial myopathy
0.44
Mitochondrial myopathy
0.44

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Cytochrome b

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis