AlphaFold predicted structure
MT-ND2 · P03891
Mean pLDDT
95.1/ 100
Very high
347 residues
Confidence breakdown
- Very high(≥ 90)94%
- Confident(70–90)6%
- Low(50–70)0%
- Very low(< 50)0%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
MT-ND2
Chr mitochondriamitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2
- Aliases:
- ND2, NAD2
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Likely inborn error of metabolism
MITOCHONDRIALMitochondrial disorders
MITOCHONDRIALUndiagnosed metabolic disorders
MITOCHONDRIALOptic neuropathy
MITOCHONDRIALAlbinism or congenital nystagmus
MITOCHONDRIALInfantile nystagmus
MITOCHONDRIALChildhood onset dystonia, chorea or related movement disorder
MITOCHONDRIAL
Disease associations (Open Targets)
Leber hereditary optic neuropathy
0.69mitochondrial disease
0.67Leigh syndrome
0.67mitochondrial complex I deficiency
0.65type 2 diabetes mellitus
0.61mitochondrial non-syndromic sensorineural hearing loss
0.59diabetes mellitus
0.58MELAS syndrome
0.57Mitochondrial non-syndromic sensorineural deafness with susceptibility to aminoglycoside exposure
0.56MERRF syndrome
0.52
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
NADH-ubiquinone oxidoreductase chain 2
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:16996290). Essential for the catalytic activity and assembly of complex I (PubMed:16996290)
Diseases associated with MT-ND2
Curated MONDO disease pages that list MT-ND2 among their top associated genes.