MT-ND3

Chr mitochondria

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3

Aliases:: ND3, NAD3

OMIM: 516002 ↗NCBI: 4537 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

MT-ND3 · P03897

v62025-08-01

Predicted Aligned Error matrix for MT-ND3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

91.9/ 100

Very high

115 residues

Confidence breakdown

Very high(≥ 90)67%
Confident(70–90)32%
Low(50–70)1%
Very low(< 50)0%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Likely inborn error of metabolism
MITOCHONDRIAL
Mitochondrial disorders
MITOCHONDRIAL
Undiagnosed metabolic disorders
MITOCHONDRIAL
Optic neuropathy
MITOCHONDRIAL
Childhood onset dystonia, chorea or related movement disorder
MITOCHONDRIAL

Disease associations (Open Targets)

Leigh syndrome
0.72
mitochondrial disease
0.67
mitochondrial complex I deficiency
0.67
type 2 diabetes mellitus
0.61
diabetes mellitus
0.58
MELAS syndrome
0.57
Isolated cytochrome C oxidase deficiency
0.52
leigh syndrome due to mitochondrial complex iv deficiency
0.52
MERRF
0.49
MERRF syndrome
0.49

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

NADH-ubiquinone oxidoreductase chain 3

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:25118196). Essential for the catalytic activity of complex I (PubMed:25118196)

Curated MONDO disease pages that list MT-ND3 among their top associated genes.

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Disease associations (Open Targets)

Protein function (UniProt)

Diseases associated with MT-ND3