MT-ND6

Chr mitochondria

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6

Aliases:: NAD6, ND6

OMIM: 516006 ↗NCBI: 4541 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

MT-ND6 · P03923

v62025-08-01

Predicted Aligned Error matrix for MT-ND6 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

84.8/ 100

Confident

174 residues

Confidence breakdown

Very high(≥ 90)52%
Confident(70–90)36%
Low(50–70)5%
Very low(< 50)7%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Likely inborn error of metabolism
MITOCHONDRIAL
Mitochondrial disorders
MITOCHONDRIAL
Optic neuropathy
MITOCHONDRIAL
Structural basal ganglia disorders
MITOCHONDRIAL
Undiagnosed metabolic disorders
MITOCHONDRIAL
Adult onset dystonia, chorea or related movement disorder
MITOCHONDRIAL
Adult onset neurodegenerative disorder
MITOCHONDRIAL
Albinism or congenital nystagmus
MITOCHONDRIAL

+6 more panels — install the extension to see the full list inline on any page.

Disease associations (Open Targets)

Leber hereditary optic neuropathy
0.74
Leigh syndrome
0.71
MELAS syndrome
0.70
mitochondrial disease
0.66
MELAS
0.64
type 2 diabetes mellitus
0.62
diabetes mellitus
0.58
Leber plus disease
0.55
mitochondrial myopathy with reversible cytochrome C oxidase deficiency
0.44
polycystic ovary syndrome
0.42

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

NADH-ubiquinone oxidoreductase chain 6

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:14595656, PubMed:8644732). Essential for the catalytic activity and assembly of complex I (PubMed:14595656, PubMed:8644732)

Curated MONDO disease pages that list MT-ND6 among their top associated genes.

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Disease associations (Open Targets)

Protein function (UniProt)

Diseases associated with MT-ND6