MT-TL1

Chr mitochondria

mitochondrially encoded tRNA-Leu (UUA/G) 1

Annotations refreshed 1 month ago.

Predicted protein structure

No predicted 3D structure for MT-TL1. Non-coding genes and pseudogenes typically have no protein product.

Diagnostic Grade (Green)

Diabetes with additional phenotypes suggestive of a monogenic aetiology
MITOCHONDRIAL
Familial diabetes
MITOCHONDRIAL
Hereditary neuropathy
MITOCHONDRIAL
Likely inborn error of metabolism
MITOCHONDRIAL
Mitochondrial disorders
MITOCHONDRIAL
Monogenic diabetes
MITOCHONDRIAL
Retinal disorders
MITOCHONDRIAL
Undiagnosed metabolic disorders
MITOCHONDRIAL

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MELAS
0.56
maternally-inherited diabetes and deafness
0.52
MELAS syndrome
0.46
hypertrophic cardiomyopathy and renal tubular disease due to mitochondrial DNA mutation
0.38
mitochondrial disease
0.37
inborn mitochondrial metabolism disorder
0.37
Macular dystrophy
0.37
MERRF
0.37
inherited retinal dystrophy
0.37
Retinal dystrophy
0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.