MUC5B

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Pulmonary fibrosis familial

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• COVID-19 research

  Unknown

• Familial pulmonary fibrosis

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

• idiopathic pulmonary fibrosis

  0.60

• interstitial lung disease

  0.55

• pulmonary fibrosis

  0.47

• COVID-19

  0.45

• respiratory system disorder

  0.44

• respiratory failure

  0.43

• postinflammatory pulmonary fibrosis

  0.42

• chronic lung disease

  0.41

• invasive mechanical ventilation

  0.38

• Abnormal lung morphology

  0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)