MUTYH

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Additional findings health related

  BIALLELIC, autosomal or pseudoautosomal

• Additional findings health related - adult specific

  BIALLELIC, autosomal or pseudoautosomal

• Additional findings health related - CNV analysis adult specific

  BIALLELIC, autosomal or pseudoautosomal

• Adult solid tumours cancer susceptibility

  BIALLELIC, autosomal or pseudoautosomal

• Adult solid tumours for rare disease

  BIALLELIC, autosomal or pseudoautosomal

• Colorectal cancer pertinent cancer susceptibility

  BIALLELIC, autosomal or pseudoautosomal

• GI tract tumours

  BIALLELIC, autosomal or pseudoautosomal

• Inherited polyposis and early onset colorectal cancer - germline testing

  BIALLELIC, autosomal or pseudoautosomal

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Disease associations (Open Targets)

• familial adenomatous polyposis 2

  0.85

• Familial adenomatous polyposis

  0.77

• gastric cancer

  0.70

• colorectal cancer

  0.62

• colon carcinoma

  0.61

• mutyh-associated polyposis

  0.59

• Inherited cancer-predisposing syndrome

  0.58

• hereditary neoplastic syndrome

  0.58

• breast carcinoma

  0.58

• colorectal adenocarcinoma

  0.55

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Diseases associated with MUTYH

Curated MONDO disease pages that list MUTYH among their top associated genes.

• gastric cancerRare
• malignant colon neoplasmRare