MX2

Chr 21q22.3

MX dynamin like GTPase 2

Aliases:: MXB
MANE:: ENST00000330714.8

OMIM: 147890 ↗NCBI: 4600 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

MX2 · P20592

v62025-08-01

Predicted Aligned Error matrix for MX2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

78.2/ 100

Confident

715 residues

Confidence breakdown

Very high(≥ 90)35%
Confident(70–90)45%
Low(50–70)5%
Very low(< 50)16%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

COVID-19 research
Unknown

Disease associations (Open Targets)

cutaneous melanoma
0.49
melanoma
0.49
skin cancer
0.40
alcohol drinking
0.28
urolithiasis
0.28
infection
0.11
HIV-1 infection
0.11
systemic lupus erythematosus
0.09
leukemia
0.08
Cone rod dystrophy
0.07

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Interferon-induced GTP-binding protein Mx2

Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression