MYH10

Chr 17p13.1

myosin heavy chain 10

Aliases:: NMMHCB
MANE:: ENST00000360416.8

OMIM: 160776 ↗NCBI: 4628 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

MYH10 · P35580

v62025-08-01

Predicted Aligned Error matrix for MYH10 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

76.2/ 100

Confident

1,976 residues

Confidence breakdown

Very high(≥ 90)18%
Confident(70–90)52%
Low(50–70)25%
Very low(< 50)5%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Structural eye disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

neurodevelopmental disorder
0.48
hereditary disease
0.45
Epicanthus inversus
0.43
Hypertelorism
0.43
Congenital ptosis
0.43
Abnormal facial shape
0.43
Midface retrusion
0.43
Wide nose
0.43
complex neurodevelopmental disorder with or without congenital anomalies
0.40
coloboma
0.39

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Myosin-10

Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9