MYL9

Chr 20q11.23

myosin light chain 9

Aliases:: MYRL2, MLC2, LC20, MRLC1
MANE:: ENST00000279022.7

OMIM: 609905 ↗NCBI: 10398 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

MYL9 · P24844

v62025-08-01

Predicted Aligned Error matrix for MYL9 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

83.8/ 100

Confident

172 residues

Confidence breakdown

Very high(≥ 90)61%
Confident(70–90)21%
Low(50–70)7%
Very low(< 50)11%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Paediatric pseudo-obstruction syndrome
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

megacystis-microcolon-intestinal hypoperistalsis syndrome 4
0.57
diabetic ketoacidosis
0.30
familial visceral myopathy
0.29
visceral myopathy 1
0.29
colorectal carcinoma
0.11
neoplasm
0.10
cancer
0.09
colorectal cancer
0.09
esophageal squamous cell carcinoma
0.08
COVID-19
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Myosin regulatory light polypeptide 9

Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (PubMed:11942626, PubMed:2526655). In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity)