MYO15A

Chr 17p11.2

myosin XVA

MANE:: ENST00000647165.2

OMIM: 602666 ↗NCBI: 51168 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

MYO15A · Q9UKN7-2isoform

No predicted structure exists for the canonical Q9UKN7 sequence; metrics below describe this isoform.

v62025-08-01

Predicted Aligned Error matrix for MYO15A — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

77.0/ 100

Confident

797 residues

Confidence breakdown

Very high(≥ 90)39%
Confident(70–90)34%
Low(50–70)9%
Very low(< 50)18%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Monogenic hearing loss
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies

Disease associations (Open Targets)

hearing loss, autosomal recessive
0.72
deafness
0.66
nonsyndromic genetic hearing loss
0.64
Rare genetic deafness
0.56
Hearing impairment
0.54
hereditary disease
0.53
Abnormality of the ear
0.51
ear malformation
0.49
Intellectual disability
0.43
Congenital sensorineural hearing impairment
0.42

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Unconventional myosin-XV

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity)

Curated MONDO disease pages that list MYO15A among their top associated genes.

hearing loss, autosomal recessiveRare

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Disease associations (Open Targets)

Protein function (UniProt)

Diseases associated with MYO15A