MYO18B

Chr 22q12.1

myosin XVIIIB

Aliases:: BK125H2.1
MANE:: ENST00000335473.12

OMIM: 607295 ↗NCBI: 84700 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

MYO18B · Q8IUG5

v62025-08-01

Predicted Aligned Error matrix for MYO18B — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

59.8/ 100

Low

2,567 residues

Confidence breakdown

Very high(≥ 90)12%
Confident(70–90)35%
Low(50–70)12%
Very low(< 50)41%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Congenital myopathy
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Skeletal dysplasia
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Klippel-Feil anomaly-myopathy-facial dysmorphism syndrome
0.79
atrial fibrillation
0.56
hereditary disease
0.45
Brugada syndrome
0.43
mathematical ability
0.42
nemaline myopathy
0.35
septic shock
0.29
immune system disorder
0.29
Cervical C2/C3 vertebral fusion
0.27
Klippel-Feil syndrome
0.27

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Unconventional myosin-XVIIIb

May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth