MYO9A

Chr 15q23

myosin IXA

Aliases:: FLJ11061, FLJ13244, MGC71859
MANE:: ENST00000356056.10

OMIM: 604875 ↗NCBI: 4649 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

MYO9A · B2RTY4

v62025-08-01

Predicted Aligned Error matrix for MYO9A — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

57.4/ 100

Low

2,548 residues

Confidence breakdown

Very high(≥ 90)4%
Confident(70–90)42%
Low(50–70)10%
Very low(< 50)45%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Congenital myaesthenic syndrome
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Arthrogryposis
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Presynaptic congenital myasthenic syndromes
0.69
presynaptic congenital myasthenic syndrome
0.40
placental abruption
0.27
adverse effect
0.26
liver disorder
0.24
hereditary disease
0.19
focal segmental glomerulosclerosis
0.18
gout
0.18
gastrointestinal disease
0.16
Flexion contracture
0.14

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Unconventional myosin-IXa

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating its GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity)