MYT1

Chr 20q13.33

myelin transcription factor 1

Aliases:: MTF1, MYTI, ZC2HC4A, NZF2, ZC2H2C1
MANE:: ENST00000328439.6

OMIM: 600379 ↗NCBI: 4661 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

MYT1 · Q01538

v62025-08-01

Predicted Aligned Error matrix for MYT1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

58.8/ 100

Low

1,121 residues

Confidence breakdown

Very high(≥ 90)6%
Confident(70–90)31%
Low(50–70)14%
Very low(< 50)49%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

neurodegenerative disease
0.44
restless legs syndrome
0.42
movement disorder
0.33
autism spectrum disorder
0.33
Abnormal pupillary function
0.31
allergic disease
0.27
Abnormal thrombosis
0.27
respiratory system disorder
0.27
Intellectual disability
0.27
coronary atherosclerosis
0.27

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Myelin transcription factor 1

Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription