AlphaFold predicted structure
MYT1L · Q9UL68
Mean pLDDT
56.1/ 100
Low
1,186 residues
Confidence breakdown
- Very high(≥ 90)5%
- Confident(70–90)28%
- Low(50–70)12%
- Very low(< 50)55%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
MYT1L
Chr 2p25.3myelin transcription factor 1 like
- Aliases:
- KIAA1106, NZF1, ZC2HC4B, ZC2H2C2
- MANE:
- ENST00000647738.2
Annotations refreshed 10 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownIntellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedSevere early-onset obesity
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedFetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Disease associations (Open Targets)
intellectual disability, autosomal dominant 39
0.76Intellectual disability
0.61obesity disorder
0.52hereditary disease
0.51Obesity
0.48obesity due to melanocortin 4 receptor deficiency
0.48Abnormality of the skeletal system
0.43neurodevelopmental disorder
0.43response to xenobiotic stimulus
0.38neurodegenerative disease
0.37
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Myelin transcription factor 1-like protein
Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes
Diseases associated with MYT1L
Curated MONDO disease pages that list MYT1L among their top associated genes.