MYZAP

Chr 15q21.3

myocardial zonula adherens protein

Aliases:: MYOZAP, Gup, Gup1, GCOM1
MANE:: ENST00000267853.10

OMIM: 614071 ↗NCBI: 100820829 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

MYZAP · P0CAP1

v62025-08-01

Predicted Aligned Error matrix for MYZAP — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

77.2/ 100

Confident

466 residues

Confidence breakdown

Very high(≥ 90)52%
Confident(70–90)13%
Low(50–70)12%
Very low(< 50)23%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Paediatric or syndromic cardiomyopathy
BIALLELIC, autosomal or pseudoautosomal
Dilated and arrhythmogenic cardiomyopathy
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

cardiomyopathy, dilated, 2K
0.66
atrial fibrillation
0.53
dilated cardiomyopathy
0.48
cardiac arrhythmia
0.43
atrial flutter
0.40
chronic obstructive pulmonary disease
0.35
DNA methylation
0.28
placental abruption
0.26
psoriatic arthritis
0.21
hereditary disease
0.19

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Myocardial zonula adherens protein

Plays a role in cellular signaling via Rho-related GTP-binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity)