NAA15

Chr 4q31.1

N-alpha-acetyltransferase 15, NatA auxiliary subunit

Aliases:: TBDN100, NATH, FLJ13340
MANE:: ENST00000296543.10

OMIM: 608000 ↗NCBI: 80155 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

NAA15 · Q9BXJ9

v62025-08-01

Predicted Aligned Error matrix for NAA15 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

89.4/ 100

Confident

866 residues

Confidence breakdown

Very high(≥ 90)78%
Confident(70–90)12%
Low(50–70)5%
Very low(< 50)5%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Paediatric or syndromic cardiomyopathy
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

intellectual disability, autosomal dominant 50
0.79
hereditary disease
0.54
Intellectual disability
0.52
neurodevelopmental disorder
0.46
neurodegenerative disease
0.45
syndromic intellectual disability
0.40
complex neurodevelopmental disorder
0.37
Global developmental delay
0.34
Neurodevelopmental delay
0.34
autism
0.34

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

N-alpha-acetyltransferase 15, NatA auxiliary subunit

Auxillary subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase (NAT) activity (PubMed:15496142, PubMed:20154145, PubMed:29754825, PubMed:32042062). The NAT activity may be important for vascular, hematopoietic and neuronal growth and development (PubMed:15496142). Required to control retinal neovascularization in adult ocular endothelial cells (PubMed:11687548). In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter (PubMed:12145306)