NAA20

Chr 20p11.23

N-alpha-acetyltransferase 20, NatB catalytic subunit

Aliases:: dJ1002M8.1, NAT3
MANE:: ENST00000334982.9

OMIM: 610833 ↗NCBI: 51126 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

NAA20 · P61599

v62025-08-01

Predicted Aligned Error matrix for NAA20 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

94.0/ 100

Very high

178 residues

Confidence breakdown

Very high(≥ 90)85%
Confident(70–90)15%
Low(50–70)1%
Very low(< 50)0%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Severe microcephaly
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

intellectual developmental disorder, autosomal recessive 73
0.52
neurodegenerative disease
0.38
autosomal recessive non-syndromic intellectual disability
0.37
liver disorder
0.13
alcohol drinking
0.11
benign thyroid gland neoplasm
0.09
urolithiasis
0.09
Abnormality of the skeletal system
0.08
hepatocellular carcinoma
0.08
glomerulonephritis
0.06

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

N-alpha-acetyltransferase 20

Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln (PubMed:34230638). Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration