NAA60

Chr 16p13.3

N-alpha-acetyltransferase 60, NatF catalytic subunit

Aliases:: FLJ14154, HAT4, NatF, hNaa60
MANE:: ENST00000407558.9

OMIM: 614246 ↗NCBI: 79903 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

NAA60 · Q9H7X0

v62025-08-01

Predicted Aligned Error matrix for NAA60 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

88.3/ 100

Confident

242 residues

Confidence breakdown

Very high(≥ 90)72%
Confident(70–90)15%
Low(50–70)6%
Very low(< 50)7%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Adult onset neurodegenerative disorder
BIALLELIC, autosomal or pseudoautosomal
Hereditary ataxia with onset in adulthood
BIALLELIC, autosomal or pseudoautosomal
White matter disorders and cerebral calcification - narrow panel
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

basal ganglia calcification, idiopathic, 9, autosomal recessive
0.68
bilateral striopallidodentate calcinosis
0.38
neurodegenerative disease
0.15
infection
0.04
cleft lip
0.02
cleft palate
0.02
cancer
0.01
gestational diabetes
0.01
type 2 diabetes mellitus
0.00
colorectal carcinoma
0.00

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

N-alpha-acetyltransferase 60

N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol (PubMed:25732826, PubMed:38480682). Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met (PubMed:21750686, PubMed:25732826, PubMed:27320834, PubMed:27550639). Required for normal chromosomal segregation during anaphase (PubMed:21750686). May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences (PubMed:21981917)