nanos C2HC-type zinc finger 3
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Moderate Evidence (Amber)
Primary ovarian insufficiency
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedneurodegenerative disease
primary ovarian failure
Abnormality of the skeletal system
Premature ovarian insufficiency
spermatogenic failure
male infertility with azoospermia or oligozoospermia due to single gene mutation
partial chromosome Y deletion
non-syndromic male infertility due to sperm motility disorder
asthma
spermatogenic failure 50
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Nanos homolog 3
Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis
NANOS3 · P60323
Mean pLDDT
70.9/ 100
Confident
173 residues
Confidence breakdown
AlphaFold (Jumper et al., 2021) · CC BY 4.0
