NAPRT

Chr 8q24.3

nicotinate phosphoribosyltransferase

Aliases:: PP3856
MANE:: ENST00000449291.7

OMIM: 611552 ↗NCBI: 93100 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

NAPRT · Q6XQN6

v62025-08-01

Predicted Aligned Error matrix for NAPRT — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

94.9/ 100

Very high

538 residues

Confidence breakdown

Very high(≥ 90)92%
Confident(70–90)6%
Low(50–70)1%
Very low(< 50)1%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Haematological malignancies cancer susceptibility
MONOALLELIC, autosomal or pseudoautosomal, paternally imprinted (maternal allele expressed)

Disease associations (Open Targets)

schizophrenia
0.15
cancer
0.10
neoplasm
0.09
frozen shoulder
0.08
colorectal carcinoma
0.08
Miyoshi myopathy
0.07
Oral ulcer
0.07
insomnia
0.07
renal cell carcinoma
0.04
glioblastoma
0.03

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Nicotinate phosphoribosyltransferase

Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate (PubMed:17604275, PubMed:21742010, PubMed:26042198). Helps prevent cellular oxidative stress via its role in NAD biosynthesis (PubMed:17604275)