NCAPD2

Chr 12p13.31

non-SMC condensin I complex subunit D2

Aliases:: CNAP1, hCAP-D2, CAP-D2, KIAA0159
MANE:: ENST00000315579.10

OMIM: 615638 ↗NCBI: 9918 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

NCAPD2 · Q15021

v62025-08-01

Predicted Aligned Error matrix for NCAPD2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

79.6/ 100

Confident

1,401 residues

Confidence breakdown

Very high(≥ 90)41%
Confident(70–90)39%
Low(50–70)6%
Very low(< 50)14%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Severe microcephaly
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

microcephaly 21, primary, autosomal recessive
0.57
autosomal recessive primary microcephaly
0.46
neurodegenerative disease
0.38
hereditary disease
0.19
hyperpituitarism
0.12
cancer
0.10
liver cancer
0.08
hepatocellular carcinoma
0.08
breast cancer
0.08
neoplasm
0.06

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Condensin complex subunit 1

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959)