NCAPD3

Chr 11q25

non-SMC condensin II complex subunit D3

Aliases:: hCAP-D3, CAP-D3, hHCP-6, KIAA0056, FLJ42888
MANE:: ENST00000534548.7

OMIM: 609276 ↗NCBI: 23310 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

NCAPD3 · P42695

v62025-08-01

Predicted Aligned Error matrix for NCAPD3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

72.4/ 100

Confident

1,498 residues

Confidence breakdown

Very high(≥ 90)28%
Confident(70–90)42%
Low(50–70)6%
Very low(< 50)24%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Severe microcephaly
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

microcephaly 22, primary, autosomal recessive
0.61
autosomal recessive primary microcephaly
0.50
placenta praevia
0.24
alcohol drinking
0.22
bronchiectasis
0.22
urolithiasis
0.21
posterior cortical atrophy
0.09
gastric cancer
0.08
neoplasm
0.08
colorectal carcinoma
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Condensin-2 complex subunit D3

Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959)