NCAPG2

Chr 7q36.3

non-SMC condensin II complex subunit G2

Aliases:: FLJ20311, MTB, CAP-G2, hCAP-G2
MANE:: ENST00000356309.8

OMIM: 608532 ↗NCBI: 54892 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

NCAPG2 · Q86XI2

v62025-08-01

Predicted Aligned Error matrix for NCAPG2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

87.8/ 100

Confident

1,143 residues

Confidence breakdown

Very high(≥ 90)62%
Confident(70–90)29%
Low(50–70)5%
Very low(< 50)4%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Limb disorders
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Khan-Khan-Katsanis syndrome
0.67
neurodegenerative disease
0.34
cancer
0.10
neoplasm
0.10
hepatocellular carcinoma
0.09
posterior cortical atrophy
0.08
Alzheimer disease
0.05
lung carcinoma
0.05
non-small cell lung carcinoma
0.05
glioma
0.05

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Condensin-2 complex subunit G2

Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis