NDE1

Chr 16p13.11

nudE neurodevelopment protein 1

Aliases:: nudE, FLJ20101, NDE
MANE:: ENST00000396354.6

OMIM: 609449 ↗NCBI: 54820 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

NDE1 · Q9NXR1

v62025-08-01

Predicted Aligned Error matrix for NDE1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

76.9/ 100

Confident

335 residues

Confidence breakdown

Very high(≥ 90)53%
Confident(70–90)10%
Low(50–70)8%
Very low(< 50)30%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Early onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Malformations of cortical development
BIALLELIC, autosomal or pseudoautosomal
Severe microcephaly
BIALLELIC, autosomal or pseudoautosomal
Cerebral vascular malformations
Inherited white matter disorders
BIALLELIC, autosomal or pseudoautosomal

+1 more panels — install the extension to see the full list inline on any page.

Disease associations (Open Targets)

lissencephaly 4
0.75
NDE1-related microhydranencephaly
0.63
aortic aneurysm, familial thoracic 4
0.55
microlissencephaly
0.52
familial thoracic aortic aneurysm and aortic dissection
0.50
megacystis-microcolon-intestinal hypoperistalsis syndrome 2
0.49
visceral myopathy 2
0.45
hydranencephaly
0.38
Lissencephaly
0.38
lissencephaly spectrum disorders
0.38

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Nuclear distribution protein nudE homolog 1

Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a postmitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. Acts as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709)