NDNF

Chr 4q27

neuron derived neurotrophic factor

Aliases:: FLJ23191
MANE:: ENST00000379692.9

OMIM: 616506 ↗NCBI: 79625 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

NDNF · Q8TB73

v62025-08-01

Predicted Aligned Error matrix for NDNF — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

78.6/ 100

Confident

568 residues

Confidence breakdown

Very high(≥ 90)44%
Confident(70–90)32%
Low(50–70)5%
Very low(< 50)20%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Hypogonadotropic hypogonadism (GMS)
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

hypogonadotropic hypogonadism 25 with anosmia
0.62
Kallmann syndrome
0.60
Abnormality of the skeletal system
0.38
neurodegenerative disease
0.37
facial morphology
0.31
acute tonsillitis
0.29
ankylosing spondylitis
0.19
syphilis
0.05
lung carcinoma
0.05
Miyoshi myopathy
0.05

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Protein NDNF

Secretory protein that plays a role in various cellular processes (PubMed:20969804, PubMed:24706764, PubMed:31883645). Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus (PubMed:31883645). Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system (PubMed:20969804, PubMed:31883645). May also act through the regulation of growth factors activity and downstream signaling (PubMed:31883645). Also regulates extracellular matrix assembly and cell adhesiveness (By similarity). Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (PubMed:24706764)