NDRG1

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Hereditary neuropathy

  BIALLELIC, autosomal or pseudoautosomal

• Hereditary neuropathy or pain disorder

  BIALLELIC, autosomal or pseudoautosomal

• Intellectual disability

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

• Charcot-Marie-Tooth disease type 4D

  0.74

• Charcot-Marie-Tooth disease type 4

  0.55

• hereditary disease

  0.45

• Charcot-Marie-Tooth disease

  0.43

• lung carcinoma

  0.39

• gastric carcinoma

  0.37

• prostate adenocarcinoma

  0.37

• colorectal adenocarcinoma

  0.37

• bile duct carcinoma

  0.37

• lymphoid neoplasm

  0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)