NDUFB10

Chr 16p13.3

NADH:ubiquinone oxidoreductase subunit B10

Aliases:: PDSW
MANE:: ENST00000268668.11

OMIM: 603843 ↗NCBI: 4716 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

NDUFB10 · O96000

v62025-08-01

Predicted Aligned Error matrix for NDUFB10 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

90.8/ 100

Very high

172 residues

Confidence breakdown

Very high(≥ 90)74%
Confident(70–90)22%
Low(50–70)3%
Very low(< 50)1%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Likely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomal
Mitochondrial disorder with complex I deficiency
BIALLELIC, autosomal or pseudoautosomal
Mitochondrial disorders
BIALLELIC, autosomal or pseudoautosomal
Possible mitochondrial disorder - nuclear genes
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

mitochondrial complex 1 deficiency, nuclear type 35
0.70
type 2 diabetes mellitus
0.61
diabetes mellitus
0.58
Parkinson disease
0.45
neurodegenerative disease
0.45
mitochondrial complex I deficiency
0.44
polycystic ovary syndrome
0.42
gestational diabetes
0.41
Insulin resistance
0.40
multiple sclerosis
0.40

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain