AlphaFold predicted structure
NDUFB3 · O43676
Mean pLDDT
86.9/ 100
Confident
98 residues
Confidence breakdown
- Very high(≥ 90)68%
- Confident(70–90)17%
- Low(50–70)5%
- Very low(< 50)9%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
NDUFB3
Chr 2q33.1NADH:ubiquinone oxidoreductase subunit B3
- Aliases:
- B12
- MANE:
- ENST00000237889.9
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
DDG2P
BIALLELIC, autosomal or pseudoautosomalFetal anomalies
BIALLELIC, autosomal or pseudoautosomalLikely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomalMitochondrial disorder with complex I deficiency
BIALLELIC, autosomal or pseudoautosomalMitochondrial disorders
BIALLELIC, autosomal or pseudoautosomalPossible mitochondrial disorder - nuclear genes
BIALLELIC, autosomal or pseudoautosomalUndiagnosed metabolic disorders
BIALLELIC, autosomal or pseudoautosomalPaediatric or syndromic cardiomyopathy
BIALLELIC, autosomal or pseudoautosomal
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Disease associations (Open Targets)
mitochondrial complex I deficiency, nuclear type 25
0.73mitochondrial complex I deficiency
0.63type 2 diabetes mellitus
0.61diabetes mellitus
0.58hereditary disease
0.49polycystic ovary syndrome
0.42gestational diabetes
0.41Insulin resistance
0.40prediabetes syndrome
0.40type 1 diabetes mellitus
0.39
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone