NDUFB4

Chr 3q13.33

NADH:ubiquinone oxidoreductase subunit B4

Aliases:: B15
MANE:: ENST00000184266.3

OMIM: 603840 ↗NCBI: 4710 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

NDUFB4 · O95168

v62025-08-01

Predicted Aligned Error matrix for NDUFB4 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

94.6/ 100

Very high

129 residues

Confidence breakdown

Very high(≥ 90)91%
Confident(70–90)9%
Low(50–70)1%
Very low(< 50)0%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Mitochondrial disorder with complex I deficiency
BIALLELIC, autosomal or pseudoautosomal
Possible mitochondrial disorder - nuclear genes
Unknown
Likely inborn error of metabolism
Unknown
Mitochondrial disorders

Disease associations (Open Targets)

type 2 diabetes mellitus
0.61
diabetes mellitus
0.58
neurodegenerative disease
0.57
Parkinson disease
0.52
multiple sclerosis
0.46
Alzheimer disease
0.44
lysosomal storage disease
0.44
polycystic ovary syndrome
0.42
gestational diabetes
0.41
Insulin resistance
0.40

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone