NDUFB6

Chr 9p21.1

NADH:ubiquinone oxidoreductase subunit B6

Aliases:: B17, CI
MANE:: ENST00000379847.8

OMIM: 603322 ↗NCBI: 4712 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

NDUFB6 · O95139

v62025-08-01

Predicted Aligned Error matrix for NDUFB6 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

90.1/ 100

Very high

128 residues

Confidence breakdown

Very high(≥ 90)59%
Confident(70–90)39%
Low(50–70)0%
Very low(< 50)2%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Mitochondrial disorder with complex I deficiency
Unknown
Possible mitochondrial disorder - nuclear genes
Unknown
Likely inborn error of metabolism
Unknown
Mitochondrial disorders

Disease associations (Open Targets)

type 2 diabetes mellitus
0.62
diabetes mellitus
0.58
neurodegenerative disease
0.56
Parkinson disease
0.45
polycystic ovary syndrome
0.42
gestational diabetes
0.41
Insulin resistance
0.41
multiple sclerosis
0.40
prediabetes syndrome
0.40
type 1 diabetes mellitus
0.39

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Curated MONDO disease pages that list NDUFB6 among their top associated genes.

gestational diabetesRare

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Disease associations (Open Targets)

Protein function (UniProt)

Diseases associated with NDUFB6