NDUFB7

Chr 19p13.12

NADH:ubiquinone oxidoreductase subunit B7

Aliases:: B18, CI-B18, MGC2480
MANE:: ENST00000215565.3

OMIM: 603842 ↗NCBI: 4713 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

NDUFB7 · P17568

v62025-08-01

Predicted Aligned Error matrix for NDUFB7 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

88.1/ 100

Confident

137 residues

Confidence breakdown

Very high(≥ 90)70%
Confident(70–90)20%
Low(50–70)6%
Very low(< 50)4%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Likely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomal
Mitochondrial disorder with complex I deficiency
BIALLELIC, autosomal or pseudoautosomal
Mitochondrial disorders
BIALLELIC, autosomal or pseudoautosomal
Possible mitochondrial disorder - nuclear genes
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

mitochondrial complex I deficiency, nuclear type 39
0.63
type 2 diabetes mellitus
0.61
diabetes mellitus
0.58
Parkinson disease
0.57
neurodegenerative disease
0.55
multiple sclerosis
0.52
lysosomal storage disease
0.51
Alzheimer disease
0.50
polycystic ovary syndrome
0.42
gestational diabetes
0.41

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone