AlphaFold predicted structure
NDUFB9 · Q9Y6M9
Mean pLDDT
95.8/ 100
Very high
179 residues
Confidence breakdown
- Very high(≥ 90)95%
- Confident(70–90)3%
- Low(50–70)1%
- Very low(< 50)1%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
NDUFB9
Chr 8q24.13NADH:ubiquinone oxidoreductase subunit B9
- Aliases:
- B22, UQOR22, LYRM3
- MANE:
- ENST00000276689.8
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
Likely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomalMitochondrial disorder with complex I deficiency
BIALLELIC, autosomal or pseudoautosomalMitochondrial disorders
BIALLELIC, autosomal or pseudoautosomalPossible mitochondrial disorder - nuclear genes
BIALLELIC, autosomal or pseudoautosomalUndiagnosed metabolic disorders
BIALLELIC, autosomal or pseudoautosomalChildhood onset dystonia, chorea or related movement disorder
Disease associations (Open Targets)
type 2 diabetes mellitus
0.61diabetes mellitus
0.58neurodegenerative disease
0.57mitochondrial complex I deficiency
0.55Parkinson disease
0.55multiple sclerosis
0.49lysosomal storage disease
0.48Alzheimer disease
0.47mitochondrial complex I deficiency, nuclear type 24
0.44polycystic ovary syndrome
0.42
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Diseases associated with NDUFB9
Curated MONDO disease pages that list NDUFB9 among their top associated genes.