NDUFC1

Chr 4q31.1

NADH:ubiquinone oxidoreductase subunit C1

Aliases:: KFYI
MANE:: ENST00000394223.2

OMIM: 603844 ↗NCBI: 4717 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

NDUFC1 · O43677

v62025-08-01

Predicted Aligned Error matrix for NDUFC1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

82.3/ 100

Confident

76 residues

Confidence breakdown

Very high(≥ 90)47%
Confident(70–90)18%
Low(50–70)33%
Very low(< 50)1%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Mitochondrial disorder with complex I deficiency
Unknown
Possible mitochondrial disorder - nuclear genes
Unknown
Likely inborn error of metabolism
Unknown
Mitochondrial disorders

Disease associations (Open Targets)

type 2 diabetes mellitus
0.61
diabetes mellitus
0.58
neurodegenerative disease
0.56
Parkinson disease
0.53
multiple sclerosis
0.48
Alzheimer disease
0.45
lysosomal storage disease
0.45
polycystic ovary syndrome
0.42
gestational diabetes
0.41
Insulin resistance
0.40

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone