AlphaFold predicted structure
NDUFS5 · O43920
Mean pLDDT
94.4/ 100
Very high
106 residues
Confidence breakdown
- Very high(≥ 90)91%
- Confident(70–90)9%
- Low(50–70)0%
- Very low(< 50)0%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
NDUFS5
Chr 1p34.3NADH:ubiquinone oxidoreductase subunit S5
- Aliases:
- CI-15k
- MANE:
- ENST00000372969.8
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
Mitochondrial disorder with complex I deficiency
UnknownPossible mitochondrial disorder - nuclear genes
UnknownLikely inborn error of metabolism
UnknownMitochondrial disorders
Disease associations (Open Targets)
type 2 diabetes mellitus
0.61Parkinson disease
0.60diabetes mellitus
0.59neurodegenerative disease
0.58multiple sclerosis
0.55Alzheimer disease
0.54lysosomal storage disease
0.53polycystic ovary syndrome
0.42gestational diabetes
0.41Insulin resistance
0.40
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Diseases associated with NDUFS5
Curated MONDO disease pages that list NDUFS5 among their top associated genes.