NDUFV3

Chr 21q22.3

NADH:ubiquinone oxidoreductase subunit V3

Aliases:: CI-10k
MANE:: ENST00000354250.7

OMIM: 602184 ↗NCBI: 4731 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

NDUFV3 · P56181

v62025-08-01

Predicted Aligned Error matrix for NDUFV3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

71.4/ 100

Confident

108 residues

Confidence breakdown

Very high(≥ 90)37%
Confident(70–90)10%
Low(50–70)27%
Very low(< 50)26%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Mitochondrial disorder with complex I deficiency
Unknown
Possible mitochondrial disorder - nuclear genes
Unknown
Likely inborn error of metabolism
Unknown
Mitochondrial disorders
Unknown

Disease associations (Open Targets)

type 2 diabetes mellitus
0.61
diabetes mellitus
0.58
polycystic ovary syndrome
0.42
gestational diabetes
0.41
Insulin resistance
0.40
prediabetes syndrome
0.40
type 1 diabetes mellitus
0.40
metabolic syndrome
0.39
obesity disorder
0.39
Obesity
0.39

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I